Computation of Transition States and its Applications in Biology

Date Thursday January 14, 2016 at 4:00 PM
Location 13-105 Center for the Health Sciences (CHS)
Speaker Lei Zhang, Ph.D., Beijing International Center for Mathematical Research and Center for Quantitative Biology, Peking University
Sponsoring Dept UCLA Biomathematics
Abstract ABSTRACT: The dynamics of complex biological systems is often driven by multiscale, rare but important events. In this talk, I will first introduce the numerical methods for computing transition states, in particular, the Optimization-based Shrinking Dimer (OSD) method we recently proposed. Then I will give two applications of rare events and transition states in biology, including boundary sharpening in zebrafish hindbrain and neuroblast delamination in Drosophila. The joint work with Qiang Du (Columbia), Qing Nie (UC Irvine), Yan Yan (HKUST).
Flyer Lei_Zhang_20161014.pdf