Cellular Variability and Information Flow in Signal Transduction Networks

Date Thursday November 03, 2016 at 4:00 PM
Location A2-342 MDCC, Moss Auditorium, Marion Davies Children Clinic
Speaker Roy Wollman, Ph.D., Assoc. Prof., Dept Integrative Biology & Physiology. Dept Chem. & Biochem., Inst. for Quantitative & Computational Biology, UCLA
Sponsoring Dept UCLA Biomathematics
Abstract Signaling networks act as sensors, or measurement devices, that provide information on the extracellular environment to allow cells to respond to environmental changes appropriately. Experimental single cell measurements of signaling responses indicated high level of response variability raising the possibility that cellular responses are limited in their biochemical accuracy. I will discuss our efforts to examine the question of the accuracy of cellular signal transduction networks. I will show how cells utilize temporal signal modulation--that is, dynamics--to reduce noise-induced information loss and increase the accuracy of cellular response. In the context of wound response signaling, I will discuss how cells communicate with each other optimally to allow for “local averaging” that increases information about their position relative to the wound. Finally, I will show that cellular population is composed of mixtures of different cellular states, and that the existence of multiple cellular states explains some of the observed cell to cell variability. Through the use of mixture of multiple classes of multivariate cellular responses combined with paracrine information sharing among cells, a cellular population can increase its response appropriately to environmental changes.
Flyer Roy_Wollman_20161103.pdf