Thermodynamics of Error Correction

Date Friday January 13, 2017 at 4:15 PM
Location A2-342 MDCC, Moss Auditorium, Marion Davies Children Clinic
Speaker Simone Pigolotti, Ph.D., Guest Scientist, Max-Planck Institute for Complex Systems Dresden, Germany
Sponsoring Dept UCLA Biomathematics
Abstract ABSTRACT: Biological systems are able to replicate information with outstanding accuracy. In biochemical reactions, such as DNA duplication, different monomers can be distinguished because of their binding energies or via non-equilibrium kinetic mechanisms. I will show how, in simple copying reactions, these two discrimination modes are mutually exclusive and lead to opposite tradeoffs between error, dissipation and reaction velocity. In multi-step reactions, such as in kinetic proofreading, these different modes can be combined to improve overall accuracy. I will conclude by discussing how the second law of thermodynamics can be used to directly relate copying accuracy with thermodynamic observables.
Flyer Simone_Pigolotti_seminar_20170113.pdf